BDBM50261180 (1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14-diazatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2,4(9),7,10-tetraen-5-one::CHEMBL493621

SMILES C[C@H]1C2Cc3cc4cc[nH]c(=O)c4cc3[C@@]1(C)CCN2CC1CC1

InChI Key InChIKey=MAWUNCMRNQYWCJ-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50261180   

TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50261180((1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50261180((1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14...)
Affinity DataEC50:  60nMAssay Description:Activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50261180((1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14...)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50261180((1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50261180((1S,17R)-14-(cyclopropylmethyl)-1,17-dimethyl-6,14...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed