BDBM50261028 CHEMBL3398466

SMILES CCN(CCn1ccc(n1)-c1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1nccn1

InChI Key InChIKey=FMDLORLPXIAIMQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50261028   

TargetOrexin receptor type 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50261028(CHEMBL3398466)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human OX2R expressed in CHO cells assessed as reduction in [Ala6,12]orexin-A-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50261028(CHEMBL3398466)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human OX1R expressed in CHO cells assessed as reduction in [Ala6,12]orexin-A-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50261028(CHEMBL3398466)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human recombinant OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50261028(CHEMBL3398466)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human recombinant OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed