BDBM50260364 CHEMBL4065603

SMILES [H][C@@]1(O[C@@H]1CCCCCCC)C(OC(=O)c1ccc(I)cc1)C(=O)NC1CCCCC1

InChI Key InChIKey=JGYPSIUZIQZSFE-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50260364   

TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 1.11E+4nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 4.5 uM of substrate Z-FR-MCA measured after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetCathepsin K(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of cathepsin K (unknown origin) peincubated for 5 mins followed by Z-FR-MCA addition by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 7.17E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 7 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.75E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 8 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 1.15E+4nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 4 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.13E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 5.5 uM of substrate Z-FR-MCA measured after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.26E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 6 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 9.78E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 5 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 1.69E+4nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 3.5 uM of substrate Z-FR-MCA measured after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 6.09E+3nMAssay Description:Reversible inhibition of human liver cathepsin L peincubated for 30 mins followed by addition of 9 uM of substrate Z-FR-MCA measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetCathepsin K(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of recombinant human cathepsin K using Z-Phe-Arg-MCA as fluorogenic substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of cathepsin L (unknown origin) using fluorogenic Z-FR-MCA as substrate preincubated for 5 mins followed by substrate addition by spectrof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Federal University of S£O Carlos

Curated by ChEMBL
LigandPNGBDBM50260364(CHEMBL4065603)
Affinity DataKi:  1.33E+3nMAssay Description:Uncompetitive inhibition of cathepsin L (unknown origin) peincubated for 30 mins followed by substrate Z-FR-MCA addition measured after 10 mins by sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed