BDBM50260140 CHEMBL4090144

SMILES c1cc(c(cc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)C(=O)NCc5ccn[nH]5)F

InChI Key InChIKey=XQUKEAYUAYTIBV-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50260140   

TargetRhodopsin kinase GRK1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 8.73E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 7.09E+3nMAssay Description:Inhibition of bovine GRK5 after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of C-terminal his6-tagged human GRK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of C-terminal his6-tagged human GRK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed