BDBM50258976 CHEMBL4095447

SMILES Nc1ncnc2n(nc(-c3cccc4ccccc34)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=WAJKANXMXJLTKT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50258976   

TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal GST-fused human EGFR cytoplasmic domain T790M/C797S mutant expressed in baculovirus expression system using TK-substrate aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of recombinant human EGFR L858R/T790M/C797S mutant using TK-substrate after 10 mins by HTRF KinEASE-TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 58nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system using TK-substrate after 25 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 58nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed