BDBM50258712 3-(4-((3-(tert-butoxymethyl)-5-isopropylisoxazol-4-yl)methoxy)-2-chlorostyryl)benzoic acid::CHEMBL513475

SMILES CC(C)c1onc(COC(C)(C)C)c1COc1ccc(\C=C\c2cccc(c2)C(O)=O)c(Cl)c1

InChI Key InChIKey=DZYAVCZWDRKSCB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258712   

TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258712(3-(4-((3-(tert-butoxymethyl)-5-isopropylisoxazol-4...)
Affinity DataEC50:  660nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258712(3-(4-((3-(tert-butoxymethyl)-5-isopropylisoxazol-4...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed