BDBM50258383 CHEMBL4063636

SMILES NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(n1)-c1ccc(F)cc1

InChI Key InChIKey=CJFKGISBMQMNDQ-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50258383   

TargetCalpain-1 catalytic subunit(Rat)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataIC50: 591nMAssay Description:Inhibition of calpain-1 in rat hippocampal slices assessed as prevention of NMDA-induced spectrin cleavage preincubated for 30 mins followed by NMDA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of human erythrocyte calpain 1 using Suc-Leu-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of Cal1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed