BDBM50258334 3-Cyano-N-(6-methylpyridin-2-yl)-4-(pyridine-3-yl)-benzamid::CHEMBL493570

SMILES Cc1cccc(NC(=O)c2ccc(-c3cccnc3)c(c2)C#N)n1

InChI Key InChIKey=PPYNQJKVTBNACU-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258334   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258334(3-Cyano-N-(6-methylpyridin-2-yl)-4-(pyridine-3-yl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258334(3-Cyano-N-(6-methylpyridin-2-yl)-4-(pyridine-3-yl)...)
Affinity DataKi:  2.04E+3nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed