BDBM50258332 3-Cyano-4-(4'-fluorophenyl)-N-(6-methylpyridin-2-yl)-benzamid::CHEMBL493569

SMILES Cc1cccc(NC(=O)c2ccc(-c3ccc(F)cc3)c(c2)C#N)n1

InChI Key InChIKey=PQSAUBAWBUVRJW-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258332   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258332(3-Cyano-4-(4'-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataIC50: 4.60nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258332(3-Cyano-4-(4'-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi:  134nMAssay Description:Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed