BDBM50258331 3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-yl)-benzamide::CHEMBL493568

SMILES Cc1cccc(NC(=O)c2ccc(-c3cccc(F)c3)c(c2)C#N)n1

InChI Key InChIKey=MGEYXYRIODCARZ-UHFFFAOYSA-N

Data  7 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50258331   

TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258331(3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed