BDBM50258318 CHEMBL4066494

SMILES CCN(CC)Cc1ccc(\C=C\c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1

InChI Key InChIKey=KFJNQHUVTVCSPY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50258318   

TargetCathepsin K(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258318(CHEMBL4066494)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human procathepsin K expressed in Escherichia coli using Z-Gly-Pro-Arg-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCathepsin B(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258318(CHEMBL4066494)
Affinity DataKi:  28nMAssay Description:Inhibition of human liver cathepsin B using Z-Phe-Arg-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258318(CHEMBL4066494)
Affinity DataKi:  56nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCathepsin S(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258318(CHEMBL4066494)
Affinity DataKi:  3.29E+3nMAssay Description:Inhibition of human cathepsin S expressed in Escherichia coli using Z-Val-Val-Arg-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed