BDBM50258313 CHEMBL4104445

SMILES NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(n1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=YMHVLTFYXPZXNN-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258313   

TargetCalpain-1 catalytic subunit(Rat)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258313(CHEMBL4104445)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of calpain-1 in rat hippocampal slices assessed as prevention of NMDA-induced spectrin cleavage preincubated for 30 mins followed by NMDA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258313(CHEMBL4104445)
Affinity DataKi:  40nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed