BDBM50258282 3-(2-chloro-4-((3-((2,6-difluorophenoxy)methyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid::CHEMBL494194

SMILES CC(C)c1onc(COc2c(F)cccc2F)c1COc1ccc(\C=C\c2cccc(c2)C(O)=O)c(Cl)c1

InChI Key InChIKey=CZCGWZPRRHCUID-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258282   

TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258282(3-(2-chloro-4-((3-((2,6-difluorophenoxy)methyl)-5-...)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258282(3-(2-chloro-4-((3-((2,6-difluorophenoxy)methyl)-5-...)
Affinity DataEC50:  720nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed