BDBM50257617 CHEMBL492556::N-((2,3-dihydrobenzofuran-3-yl)methyl)-N-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-sulfonamide

SMILES CN(CC1COc2ccccc12)S(=O)(=O)c1ccc2CCNCCc2c1

InChI Key InChIKey=OPBJBLKJIWYZGA-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257617   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257617(N-((2,3-dihydrobenzofuran-3-yl)methyl)-N-methyl-2,...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257617(N-((2,3-dihydrobenzofuran-3-yl)methyl)-N-methyl-2,...)
Affinity DataEC50: >9.94E+3nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257617(N-((2,3-dihydrobenzofuran-3-yl)methyl)-N-methyl-2,...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50257617(N-((2,3-dihydrobenzofuran-3-yl)methyl)-N-methyl-2,...)
Affinity DataKi:  2.99E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed