BDBM50257611 CHEMBL522349::N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-sulfonamide

SMILES Fc1ccccc1NS(=O)(=O)c1ccc2CCNCCc2c1

InChI Key InChIKey=QHWXSLUJCJOQFF-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257611   

Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257611(N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257611(N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Affinity DataEC50:  197nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257611(N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Affinity DataKi:  133nMAssay Description:Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed