BDBM50257541 (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide (Inh_VU0359595)::CHEMBL524182::racemic trans-N-((S)-1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-phenylcyclopropanecarboxamide

SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1

InChI Key InChIKey=JSVNNLRZCJAYTQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50257541   

TargetPhospholipase D1(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 36nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 1.20E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D(Streptomyces sp. PMF)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 50nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of GFP-labelled human PLD2 HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human PLD1 in Calu1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PLD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
University of Massachusetts Boston

LigandPNGBDBM50257541(CHEMBL524182 | (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of PLD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed