BDBM50257428 CHEMBL4075992

SMILES COc1ccccc1CNC(=O)c1cccc(NCc2nnc(-c3ccncc3)n2C)c1

InChI Key InChIKey=RHFRJOMKPVPGGP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257428   

TargetBeta-adrenergic receptor kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50257428(CHEMBL4075992)
Affinity DataIC50: 44nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50257428(CHEMBL4075992)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 to 553 residues) expressed in baculovirus expression system using STK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50257428(CHEMBL4075992)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKCalpha active using MBP as substrate after 60 mins in presence of [gamma-32]ATP by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed