BDBM50257239 CHEMBL447677::His-Lys-Lys(epsilon-thioAc)-Leu-Met

SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(O)=O

InChI Key InChIKey=RPADRBKCRCLQJX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50257239   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged SIRT1 expressed in Escherichia coli after 10 mins by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged SIRT2 expressed in Escherichia coli after 60 mins by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant SIRT1 preincubated for 5 mins before addition of substrate measured after 1 hr by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant SIRT2 preincubated for 5 mins before addition of substrate measured after 3 hrs by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50257239(His-Lys-Lys(epsilon-thioAc)-Leu-Met | CHEMBL447677)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of human recombinant SIRT6 assessed as 7-amino-4-methylcoumarin labelled Arg-His-Lys-Lys(epsilon-acetyl) substrate deacetylation after 90 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed