BDBM50256479 CHEMBL448929::N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide

SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2cccc(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=SKFDSQFYKXYVPS-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50256479   

TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 54nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 710nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256479(N-(2,6-difluorophenyl)-3-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed