BDBM50256044 5-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one::CHEMBL481333::Hymenialdisine, 27d

SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3ccccc3c12

InChI Key InChIKey=SMPPSGXPGZSJCP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50256044   

TargetCyclin-dependent kinase 5 activator 1(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 177nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 800nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 64nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Chk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 177nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 237nMAssay Description:Inhibition of Chk1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50256044(CHEMBL481333 | Hymenialdisine, 27d | 5-(2-amino-4-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Chk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed