BDBM50255953 2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole::CHEMBL481547

SMILES CC1(CCCCCCC1)N1CCC(CC1)n1c(nc2ccccc12)-c1ccc(F)c(Cl)c1

InChI Key InChIKey=MIFPMFZKWFDLIO-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50255953   

TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataEC50:  759nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataKi:  45nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed