BDBM50255738 (+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)benzylamino)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide::CHEMBL481010

SMILES CSc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1

InChI Key InChIKey=IRFAACFLDYQOTR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50255738   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255738((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255738((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255738((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Affinity DataIC50: 22.5nMAssay Description:Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed