BDBM50255235 CHEMBL4078924

SMILES Cc1cccc(Cn2nc(cc2-c2ccc(O)cc2)C(=O)N2CCC(Cc3ccccc3)CC2)c1

InChI Key InChIKey=BEMNHSXPLHOLFP-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50255235   

TargetMonoacylglycerol lipase ABHD6(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]CP55,940 from human CB2 receptor expressed in CHOK1 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FAAH using AMC arachidonoylamide as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human MAGL using 4-NPA as substrate after 10 mins in presence of DTT by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetLysophosphatidylserine lipase ABHD12(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABHD12 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]CP55,940 from human CB1 receptor expressed in CHOK1 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant human MAGL using 4-NPA as substrate after 30 mins by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant human MAGL using 4-NPA as substrate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataKi:  412nMAssay Description:Competitive inhibition of recombinant human MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed