BDBM50255029 CHEMBL480219::{1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-phenyl]-1H-imidazol-2-yl}-[4-(3-fluoro-phenylamino)-piperidin-1-yl]-methanone

SMILES C[C@H]1CN(Cc2ccc(cc2)-n2ccnc2C(=O)N2CCC(CC2)Nc2cccc(F)c2)C[C@@H](C)N1

InChI Key InChIKey=BKNPWPRZETXJRA-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50255029   

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of CYP3A4 using phenyl-piperazinyl-methyl-benzyl-resofurin substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human ERG bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataEC50:  501nMAssay Description:Inhibition of human Ghrelin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255029({1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-...)
Affinity DataEC50:  15.8nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed