BDBM50254387 CHEMBL4062193

SMILES Fc1ccc(Nc2n[nH]c3cc(OC(F)(F)F)cnc23)cc1F

InChI Key InChIKey=QGIXOJCLJSPCPO-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50254387   

LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of Nav1.7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human TRPA1 by calcium flux based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of full length human TRPA1 oS5 chimera at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat TRPA1 at a holding potential of 15 mV measured after 1 min by whole-cell manual patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at human TRPA1 by calcium flux based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed