BDBM50253818 2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetic Acid::CHEMBL460355

SMILES CN1CC(C)(COc2ccc(cc2)C(N)=N)Oc2cc(ccc12)N(Cc1ccccc1)C(=O)C(O)=O

InChI Key InChIKey=TVTJPMOFUPMWSY-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50253818   

TargetIntegrin alpha-IIb(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of fibrinogen binding to human platelet GPIIb/IIIa receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of biotinylated fibrinogen from human alpha2b-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of biotinylated fibrinogen from human alpha5-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataKi:  190nMAssay Description:Inhibition of thrombin using S-2238 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataKi:  377nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataKi:  1.66E+4nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253818(2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-d...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of factor 10a using S-2222 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed