BDBM50253817 CHEMBL460144::Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetate

SMILES CCOC(=O)C(=O)N(Cc1ccccc1)c1ccc2N(C)CC(C)(COc3ccc(cc3)C(N)=N)Oc2c1

InChI Key InChIKey=PZUWUDNQJZKYRR-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50253817   

TargetIntegrin alpha-IIb(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of fibrinogen binding to human platelet GPIIb/IIIa receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataIC50: 5.20E+4nMAssay Description:Displacement of biotinylated fibrinogen from human alpha2b-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of biotinylated fibrinogen from human alpha5-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataKi:  42nMAssay Description:Inhibition of thrombin using S-2238 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataKi:  110nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataKi:  1.12E+5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253817(Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]...)
Affinity DataKi:  1.12E+5nMAssay Description:Inhibition of factor 10a using S-2222 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed