BDBM50253755 5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL518046

SMILES Cc1c(nn(c1-c1ccc(Cl)s1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1

InChI Key InChIKey=FHERKDAGTCJXFZ-UHFFFAOYSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50253755   

TargetCannabinoid receptor 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253755(5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4...)
Affinity DataIC50: 50.2nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253755(5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4...)
Affinity DataIC50: 1.29E+3nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253755(5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4...)
Affinity DataEC50:  147nMAssay Description:Antagonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of Eu-GTP bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253755(5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4...)
Affinity DataEC50:  2.37E+4nMAssay Description:Antagonist activity at human cannabinoid CB2 receptor expressed in CHOK1 cells assessed as cAMP activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50253755(5-(5-Chlorothiophen-2-yl)-1-(2,4-dichlorophenyl)-4...)
Affinity DataEC50:  580nMAssay Description:Antagonist activity at human cannabinoid CB1 receptor expressed in CHOK1 cells assessed as cAMP activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed