BDBM50253281 CHEMBL522691::N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide::US20240199555, Reference LP211

SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccc(cc1)C#N

InChI Key InChIKey=BQEDZLDNNBDKDS-UHFFFAOYSA-N

Data  19 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50253281   

Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataIC50: 0.160nMAssay Description:The new compounds have been tested by radioligand binding competition activity at the human 5-HT1A (FAST-0500B), 5-HT2A (FAST-0505B), 5-HT2Cedited (F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 7(Guinea pig)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.110nMAssay Description:The new compounds have been tested by radioligand binding competition activity at the human 5-HT1A (FAST-0500B), 5-HT2A (FAST-0505B), 5-HT2Cedited (F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to rat cloned 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to rat 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-5-CT from human cloned 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-prazosin from rat brain alpha1 adrenergic receptor after 50 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]spiroperidol from human cloned dopamine D2L receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  242nMAssay Description:Binding affinity to dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  379nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor after 1.5 hrs by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  379nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor transfected in HEK293-EBNA cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi:  1.57E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor after 1.5 hrs by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50253281(N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazin...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed