BDBM50253091 CHEMBL4083081

SMILES Cc1nnc2sc(C(=O)NC3CN(C3)c3ccc(nc3)C(F)(F)F)c(N)c2c1C

InChI Key InChIKey=BPAKJFLUBIRQKF-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50253091   

TargetCytochrome P450 1A2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataEC50:  960nMAssay Description:Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50253091(CHEMBL4083081)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed