BDBM50252861 CHEMBL507214::H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2

SMILES C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(N)=O

InChI Key InChIKey=PZWWYAHWHHNCHO-UHFFFAOYSA-N

Data  3 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50252861   

TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataIC50: 2.80nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]naloxone toOpioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataEC50:  100nMAssay Description:Effective concentration required for maximum agonist response at melanocortin 1 receptor from frog skin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity against mu opioid receptor in guinea pig ileum assessed as effect on TAPP-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataIC50: 1.35E+4nMAssay Description:Antagonist activity against delta opioid receptor in mouse vas deference assessed as effect on DPDPE-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DAMGO from MOR in rat brain membrane measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataKi:  258nMAssay Description:Displacement of [3H]DSLET from DOR in rat brain membrane measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Clinical Research Institute of Montreal

Curated by ChEMBL
LigandPNGBDBM50252861(H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | CHEM...)
Affinity DataKi:  1.49E+4nMAssay Description:Displacement of [3H]U69,593 from KOR in guinea pig brain membrane measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed