BDBM50252193 4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one::4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one::CHEMBL482101

SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC2(CC1)OCCO2

InChI Key InChIKey=OQEBLEZRSCIFJK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50252193   

TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 75nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 121nMAssay Description:Inhibition of IGF1R in mouse SAL cells assessed as thymidine incorporationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP3A4 after 20 mins by BFC fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed