BDBM50251436 CHEMBL4091320

SMILES COCCn1cc(-c2ccncc2)c2ccncc12

InChI Key InChIKey=OVRGOPVESVCREL-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50251436   

TargetNuclear factor of activated T-cells, cytoplasmic 1(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataEC50:  6.90E+3nMAssay Description:Induction of nuclear translocation of human GFP-tagged NFATc1 expressed in virus infected primary human skeletal muscle myoblasts after 3 hrs by DAPI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged GSK3B recombinant in baculovirus expression system using Alexa-Fluor tracer-236 incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataIC50: 272nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of recombinant human His/GST-tagged GSK3beta (2 to 433 residues) expressed in baculovirus infected Sf9 cells using Ulight-glycogen synthas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50251436(CHEMBL4091320)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells incubated for 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed