BDBM50251391 (2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorothiazol-2-yl)-3-(tetrahydropyran-4-yl)propionamide::(R)-2-(4-(cyclopropylsulfonyl)phenyl)-N-(5-fluorothiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide::CHEMBL499520

SMILES Fc1cnc(NC(=O)[C@H](CC2CCOCC2)c2ccc(cc2)S(=O)(=O)C2CC2)s1

InChI Key InChIKey=DBMFNEZMJWKKPU-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50251391   

TargetHexokinase-4(Human)
(Osi) Prosidion

Curated by ChEMBL
LigandPNGBDBM50251391((2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorot...)
Affinity DataEC50:  130nMAssay Description:Activation of GST fused human liver glucokinase assessed as generation of NADPH by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
(Osi) Prosidion

Curated by ChEMBL
LigandPNGBDBM50251391((2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorot...)
Affinity DataEC50:  89nMAssay Description:Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
(Osi) Prosidion

Curated by ChEMBL
LigandPNGBDBM50251391((2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorot...)
Affinity DataEC50:  62nMAssay Description:Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
(Osi) Prosidion

Curated by ChEMBL
LigandPNGBDBM50251391((2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorot...)
Affinity DataEC50:  180nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed