BDBM50251279 (S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoate::CHEMBL457092

SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1

InChI Key InChIKey=WGNKTWBIPBOGLO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50251279   

TargetBaculoviral IAP repeat-containing protein 2(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50: 690nMAssay Description:Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50: 690nMAssay Description:Degradation promoting activity of FLAG tagged cIAP1 expressed in human HT1080 cells after 3 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetXaa-Pro dipeptidase(Human)
Memorial Sloan Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human PEPD using Ala-Pro as substrate assessed as alanine release by measuring increase in fluorescense signal by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetXaa-Pro aminopeptidase 1(Human)
Memorial Sloan Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50251279((S)-methyl 2-((2S,3R)-3-amino-2-hydroxy-4-phenylbu...)
Affinity DataIC50: 2.98E+5nMAssay Description:Inhibition of 6-His tagged XPNPEP1 (unknown origin) expressed in Escherichia coli Rosetta DE3 cells using H-Lys(abz)-Pro-Pro-pNA as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed