BDBM50250891 CHEMBL4064118::US11168070, Example 81

SMILES C[C@H]1Nc2c(NC1=O)cccc2N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F

InChI Key InChIKey=LDZHSQZMAXZDJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250891   

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50250891(CHEMBL4064118 | US11168070, Example 81)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50250891(CHEMBL4064118 | US11168070, Example 81)
Affinity DataIC50: 61nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50250891(CHEMBL4064118 | US11168070, Example 81)
Affinity DataIC50: 102nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent