BDBM50250839 6-bromo-2'-de-N-methylaplysinopsin::CHEMBL2058413::CHEMBL511879

SMILES CN1C(N)=NC(=Cc2c[nH]c3cc(Br)ccc23)C1=O

InChI Key InChIKey=AKOYYWJWILIASW-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250839   

TargetPlasmepsin II(Plasmodium falciparum)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlasmepsin II(Plasmodium falciparum)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataIC50: 165nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]mesulergine form human cloned 5HT2C receptor expressed in african green monkey COS7 cells by scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50250839(CHEMBL2058413 | CHEMBL511879 | 6-bromo-2'-de-N-met...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]methylspiperone form human cloned 5HT2A receptor expressed in african green monkey COS7 cells by scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed