BDBM50250527 CHEMBL4066837

SMILES [H][C@@]1(CCCN1)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(N[C@@H](C)CC)nc(c1)S(C)(=O)=O

InChI Key InChIKey=CNZLAHITQXPOEJ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50250527   

TargetBeta-secretase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50250527(CHEMBL4066837)
Affinity DataIC50: 5nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50250527(CHEMBL4066837)
Affinity DataIC50: 101nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)