BDBM50250335 CHEMBL4077034

SMILES Cc1cc(ccn1)-c1cc(Nc2nn(C)cc2Cl)nc2[nH]cc(C#N)c12

InChI Key InChIKey=GWXOHWFGHCKSOB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50250335   

LigandPNGBDBM50250335(CHEMBL4077034)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human wild type LRRK2 phosphorylation at ser935 expressed in BacMam transduced HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50250335(CHEMBL4077034)
Affinity DataIC50: 180nMAssay Description:Inhibition of wild type recombinant human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50250335(CHEMBL4077034)
Affinity DataIC50: 158nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50250335(CHEMBL4077034)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human wild type LRRK2 phosphorylation at ser935 expressed in BacMam transduced HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed