BDBM50250012 CHEMBL4080552::US11208411, Compound MLC468

SMILES Nc1ncnc2n(CC3CCNCC3)nc(Cc3cc(F)cc(F)c3)c12

InChI Key InChIKey=YJNHTFUUPURWMM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50250012   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of California

Curated by ChEMBL
LigandPNGBDBM50250012(CHEMBL4080552 | US11208411, Compound MLC468)
Affinity DataIC50: 173nMAssay Description:Inhibition of C-terminal His-tagged full length Toxoplasma gondii CDPK1 expressed in Escherichia coli BL21 (DE3) using syntide-2 as substrate pre-inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50250012(CHEMBL4080552 | US11208411, Compound MLC468)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Src kinase domain (254 to 536 residues) expressed in Escherichia coli BL21 (DE3) using abltide as substrate pre-incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of California

US Patent
LigandPNGBDBM50250012(CHEMBL4080552 | US11208411, Compound MLC468)
Affinity DataIC50: 173nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50250012(CHEMBL4080552 | US11208411, Compound MLC468)
Affinity DataIC50: 1.00E+4nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent