BDBM50250010 CHEMBL4069866::US11208411, Compound FUR7-77

SMILES Cc1cccc(Sc2nn(CC3CCNCC3)c3ncnc(N)c23)c1

InChI Key InChIKey=JBBMCVYXSKRHOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50250010   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of California

Curated by ChEMBL
LigandPNGBDBM50250010(CHEMBL4069866 | US11208411, Compound FUR7-77)
Affinity DataIC50: 517nMAssay Description:Inhibition of C-terminal His-tagged full length Toxoplasma gondii CDPK1 expressed in Escherichia coli BL21 (DE3) using syntide-2 as substrate pre-inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50250010(CHEMBL4069866 | US11208411, Compound FUR7-77)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Src kinase domain (254 to 536 residues) expressed in Escherichia coli BL21 (DE3) using abltide as substrate pre-incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of California

US Patent
LigandPNGBDBM50250010(CHEMBL4069866 | US11208411, Compound FUR7-77)
Affinity DataIC50: 517nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50250010(CHEMBL4069866 | US11208411, Compound FUR7-77)
Affinity DataIC50: 1.00E+4nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent