BDBM50249996 CHEMBL4097112::US11208411, Compound GXJ178

SMILES CC(C)(C)n1nc(Oc2cccc(c2)C(F)(F)F)c2c(N)ncnc12

InChI Key InChIKey=ALCIEJZDGYBETD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249996   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of California

Curated by ChEMBL
LigandPNGBDBM50249996(CHEMBL4097112 | US11208411, Compound GXJ178)
Affinity DataIC50: 35nMAssay Description:Inhibition of C-terminal His-tagged full length Toxoplasma gondii CDPK1 expressed in Escherichia coli BL21 (DE3) using syntide-2 as substrate pre-inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50249996(CHEMBL4097112 | US11208411, Compound GXJ178)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Src kinase domain (254 to 536 residues) expressed in Escherichia coli BL21 (DE3) using abltide as substrate pre-incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of California

US Patent
LigandPNGBDBM50249996(CHEMBL4097112 | US11208411, Compound GXJ178)
Affinity DataIC50: 35.1nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50249996(CHEMBL4097112 | US11208411, Compound GXJ178)
Affinity DataIC50: 1.00E+4nMAssay Description:Full length CDPK1 was PCR amplified from a T. gondii RH cDNA library generated using the SMART cDNA synthesis kit (Clontech). The primers contained r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent