BDBM50249680 2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione::CHEMBL499103

SMILES Cc1ccc(CNN2C(=O)c3c(C2=O)c2c4ccc(O)cc4n(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c2c2[nH]c4cc(O)ccc4c32)cc1

InChI Key InChIKey=BKTZMKDFILCMTJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249680   

TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249680(2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-...)
Affinity DataEC50:  800nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249680(2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed