BDBM50249652 CHEMBL4103847

SMILES Cc1cc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)no1

InChI Key InChIKey=FVKOYFLAKSGBBV-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50249652   

TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataEC50:  61nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IFNalpha-mediated inhibition of HCV genotype 1b RNA replication in human HuH luc/neo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50249652(CHEMBL4103847)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of 3H-dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed