BDBM50249549 CHEMBL473418::US20240115577, Compound 14::cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)(pyrrolidin-1-yl)methanone

SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncccn1)N1CCCC1

InChI Key InChIKey=KPWCBSSCODQEOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249549   

TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249549(cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)p...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human plasma DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249549(cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)p...)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of human recombinant DPP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249549(cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)p...)
Affinity DataIC50: 9.69E+3nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249549(cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)p...)
Affinity DataIC50: 3.30nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent