BDBM50249520 CHEMBL516246::N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide::N-(4-chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide

SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccc(cc2[nH]1)N(C)C

InChI Key InChIKey=UBHJFPVTEATUFS-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249520   

TargetSmoothened homolog(Mouse)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50249520(N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidaz...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249520(N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidaz...)
Affinity DataEC50:  40nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed