BDBM50249519 CHEMBL480889::N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-N-(3-methoxybenzyl)-3,3-dimethylbutanamide

SMILES COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1

InChI Key InChIKey=WPHXYKUPFJRJDK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249519   

TargetSonic hedgehog protein(Mouse)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 100nMAssay Description:Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed