BDBM50249516 CHEMBL514011::cis-2-(4-((3S,5S)-5-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidin-3-yl)piperazin-1-yl)nicotinonitrile

SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncccc1C#N

InChI Key InChIKey=NOMKZQKLENFAJZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249516   

TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249516(cis-2-(4-((3S,5S)-5-(3,3-difluoropyrrolidine-1-car...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human plasma DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249516(cis-2-(4-((3S,5S)-5-(3,3-difluoropyrrolidine-1-car...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant DPP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249516(cis-2-(4-((3S,5S)-5-(3,3-difluoropyrrolidine-1-car...)
Affinity DataIC50: 9.15E+3nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50249516(cis-2-(4-((3S,5S)-5-(3,3-difluoropyrrolidine-1-car...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed