BDBM50249416 CHEMBL471776::N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-2-yl)pyrimidin-2-amine

SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F

InChI Key InChIKey=LZZSVMHMGFYOIP-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249416   

TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of SYK-mediated FCepsilonRI signaling activity by mast cell degranulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataKi:  110nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataKi:  891nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataKi:  1.36E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249416(N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed