BDBM50249356 CHEMBL453217::N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyrimidin-2-amine

SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1

InChI Key InChIKey=IUVDZGOUQXJDQC-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249356   

TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SYK-mediated FCepsilonRI signaling activity by mast cell degranulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataKi:  56nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataKi:  100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataKi:  1.03E+3nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyr...)
Affinity DataKi:  2.03E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed